:root {
  --navy: #071724;
  --navy-2: #0d2939;
  --ink: #112837;
  --muted: #526675;
  --paper: #f4f0e7;
  --white: #fffdf8;
  --line: #d7d1c5;
  --cyan: #43d6c7;
  --cyan-deep: #08746d;
  --orange: #f69a5d;
  --red: #be554e;
  --gold: #b6812a;
  --sans: "Microsoft YaHei UI", "Microsoft YaHei", "PingFang SC", system-ui, sans-serif;
  --shadow: 0 24px 70px rgba(7, 23, 36, .13);
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body { margin: 0; color: var(--ink); background: var(--paper); font: 17.5px/1.78 var(--sans); text-rendering: optimizeLegibility; }
a { color: var(--cyan-deep); text-underline-offset: .2em; }
a:hover { color: #04514d; }
button, input, select { font: inherit; }
button, a { -webkit-tap-highlight-color: transparent; }
:focus-visible { outline: 3px solid var(--orange); outline-offset: 3px; }
.wrap { width: min(1440px, calc(100% - 64px)); margin-inline: auto; }
.skip { position: fixed; top: -6rem; left: 1rem; z-index: 100; background: white; padding: .6rem 1rem; }
.skip:focus { top: 1rem; }
.scroll-meter { position: fixed; inset: 0 0 auto; z-index: 80; height: 4px; }
.scroll-meter span { display: block; width: 0; height: 100%; background: linear-gradient(90deg, var(--cyan), var(--orange)); }

.hero { color: white; min-height: 760px; overflow: hidden; position: relative; background: radial-gradient(circle at 78% 18%, rgba(67,214,199,.19), transparent 31rem), linear-gradient(135deg, #071724 0%, #092337 60%, #103849 100%); }
.hero::after { content: ""; position: absolute; right: -220px; bottom: -330px; width: 640px; height: 640px; border: 1px solid rgba(255,255,255,.12); border-radius: 50%; box-shadow: 0 0 0 90px rgba(255,255,255,.025), 0 0 0 180px rgba(255,255,255,.016); }
.nav { min-height: 88px; display: flex; align-items: center; justify-content: space-between; border-bottom: 1px solid rgba(255,255,255,.14); position: relative; z-index: 2; }
.brand { display: flex; gap: .65rem; align-items: center; color: white; text-decoration: none; }
.brand > span { display: grid; place-items: center; width: 34px; height: 34px; border: 1px solid var(--cyan); color: var(--cyan); border-radius: 50%; font: 700 23px/1 Georgia, serif; }
.brand b { font-size: 16px; letter-spacing: .02em; }
.nav-links { display: flex; gap: 1.6rem; }
.nav-links a { color: #d5e2e9; text-decoration: none; font-size: 15.5px; }
.nav-links a:hover { color: white; }
.hero-grid { min-height: 670px; padding: 64px 0 90px; display: grid; grid-template-columns: 1.08fr .92fr; align-items: center; gap: clamp(3rem, 7vw, 8rem); position: relative; z-index: 2; }
.kicker { margin: 0 0 1rem; color: var(--cyan); font-size: 13.5px; line-height: 1.4; letter-spacing: .17em; font-weight: 800; }
.kicker.dark { color: var(--cyan-deep); }
.hero h1 { margin: 0; max-width: 900px; font-size: clamp(45px, 5.6vw, 82px); line-height: 1.07; letter-spacing: -.045em; }
.hero h1 em { color: var(--cyan); font-style: normal; }
.lede { max-width: 760px; margin: 1.6rem 0; color: #c7d6de; font-size: clamp(18px, 1.5vw, 22px); line-height: 1.7; }
.hero-actions { display: flex; flex-wrap: wrap; gap: .8rem; margin: 2rem 0 1.25rem; }
.button { min-height: 49px; display: inline-flex; align-items: center; justify-content: center; padding: .75rem 1.15rem; border-radius: 3px; font-size: 16px; font-weight: 800; text-decoration: none; }
.button.primary { color: var(--navy); background: var(--cyan); }
.button.primary:hover { background: #72e2d6; }
.button.ghost { color: white; border: 1px solid rgba(255,255,255,.34); }
.fine { color: #8fa7b4; font-size: 14px; }
.hero-board { padding: clamp(1.5rem, 3vw, 2.7rem); background: rgba(255,255,255,.075); border: 1px solid rgba(255,255,255,.16); box-shadow: 0 35px 80px rgba(0,0,0,.24); backdrop-filter: blur(10px); }
.board-title { color: #98afbb; font-size: 14px; letter-spacing: .08em; }
.big-stat { display: flex; align-items: center; gap: 1.3rem; padding: 1.4rem 0 1.55rem; border-bottom: 1px solid rgba(255,255,255,.13); }
.big-stat strong { color: var(--cyan); font: 700 82px/.9 Georgia, serif; }
.big-stat span { color: white; font-weight: 800; line-height: 1.5; }
.mini-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 1px; background: rgba(255,255,255,.13); margin: 1.3rem 0; }
.mini-grid article { min-height: 112px; padding: 1rem; background: #112c3b; }
.mini-grid strong, .mini-grid span { display: block; }
.mini-grid strong { color: var(--orange); font-size: 30px; }
.mini-grid span { color: #b7c8d1; font-size: 14px; line-height: 1.55; }
.hero-board > p { margin: 0; color: #b9cbd4; font-size: 14.5px; line-height: 1.65; }

.section-head { max-width: 930px; margin-bottom: 3rem; }
.section-head h2, .downloads h2 { margin: .1rem 0 .8rem; font-size: clamp(34px, 4vw, 55px); line-height: 1.18; letter-spacing: -.04em; }
.section-head > p:last-child { color: var(--muted); font-size: 19px; }
.section-head.light h2, .section-head.light > p:last-child { color: white; }
.section-head.light > p:last-child { color: #b9cbd4; }
.verdict { padding: 110px 0 90px; }
.verdict-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 18px; }
.verdict-card { position: relative; min-height: 330px; padding: 1.7rem; background: var(--white); border: 1px solid var(--line); box-shadow: 0 10px 32px rgba(7,23,36,.05); }
.verdict-card::before { content: ""; position: absolute; inset: 0 auto 0 0; width: 5px; background: var(--cyan-deep); }
.verdict-card.signal-warn::before { background: var(--gold); }
.verdict-card.signal-bad::before { background: var(--red); }
.verdict-card > span { color: var(--cyan-deep); font-size: 13px; letter-spacing: .1em; font-weight: 800; }
.signal-warn > span { color: #956719; }
.signal-bad > span { color: var(--red); }
.verdict-card h3 { margin: 1.35rem 0 1rem; font-size: 27px; line-height: 1.35; }
.verdict-card p { color: var(--muted); font-size: 16px; line-height: 1.75; }
.signal-strip { margin-top: 26px; display: grid; grid-template-columns: 1fr auto 1fr 1.35fr; gap: 1.3rem; align-items: center; padding: 1.5rem 1.7rem; color: white; background: var(--navy); }
.signal-strip article { display: grid; }
.signal-strip time { color: var(--cyan); font-size: 13px; }
.signal-strip article:nth-of-type(2) time { color: var(--orange); }
.signal-strip strong { font-size: 20px; }
.signal-strip span { color: #afc2cc; font-size: 14px; }
.signal-strip i { color: var(--orange); font: 400 26px/1 Georgia, serif; }
.signal-strip p { margin: 0; color: #d1dce2; font-size: 15px; line-height: 1.65; }
.negative-board { margin-top: 18px; padding: 1.35rem 1.5rem; display: grid; grid-template-columns: .65fr 1.35fr; gap: 2rem; align-items: center; background: #ebe5da; border: 1px solid #d2cabd; }
.negative-board > div span { color: var(--red); font-size: 12.5px; font-weight: 800; letter-spacing: .1em; }
.negative-board h3 { margin: .25rem 0 0; font-size: 26px; }
.negative-board ul { margin: 0; padding: 0; display: grid; grid-template-columns: repeat(4, 1fr); gap: 1px; list-style: none; background: #cfc7ba; }
.negative-board li { min-height: 72px; padding: .75rem; background: var(--white); }
.negative-board b, .negative-board li span { display: block; }
.negative-board b { font-size: 14px; }
.negative-board li span { color: var(--muted); font-size: 12px; line-height: 1.45; }

.method-band { padding: 75px 0; color: white; background: var(--navy-2); }
.method-grid { display: grid; grid-template-columns: .62fr 1.38fr; gap: 5rem; }
.method-grid h2 { margin: 0; font-size: 39px; line-height: 1.25; }
.method-items { display: grid; grid-template-columns: 1fr 1fr; gap: 1.3rem 2.3rem; }
.method-items article { border-top: 1px solid rgba(255,255,255,.18); padding-top: 1rem; }
.method-items b, .method-items span { display: block; }
.method-items b { color: var(--cyan); margin-bottom: .35rem; }
.method-items span { color: #b7c9d2; font-size: 15px; line-height: 1.65; }

.evidence { padding: 110px 0; }
.evidence-head { max-width: none; display: flex; justify-content: space-between; gap: 3rem; align-items: end; }
.evidence-head > div:first-child { max-width: 880px; }
.legend { display: grid; gap: .25rem; flex: 0 0 auto; padding-bottom: .5rem; color: var(--muted); font-size: 13px; }
.legend span { display: flex; align-items: center; gap: .5rem; }
.dot { width: 9px; height: 9px; border-radius: 50%; background: #5ca479; }
.dot.abstract { background: #c88f39; }
.dot.release { background: #b6574e; }
.dot.registry { background: #758696; }
.filters { display: grid; grid-template-columns: minmax(250px, 1.5fr) repeat(4, 1fr) auto; gap: .7rem; padding: 1rem; background: #e5dfd4; border: 1px solid #d2cabd; }
.filters label { display: grid; gap: .3rem; }
.filters label > span { color: var(--muted); font-size: 12.5px; font-weight: 800; letter-spacing: .06em; }
.filters input, .filters select { width: 100%; min-height: 47px; padding: .55rem .7rem; color: var(--ink); background: var(--white); border: 1px solid #c8c0b3; border-radius: 0; font-size: 15px; }
.filters button, .result-line button { align-self: end; min-height: 47px; padding: .55rem .9rem; cursor: pointer; color: var(--ink); background: transparent; border: 1px solid #aaa294; font-size: 14px; font-weight: 800; }
.result-line { display: flex; align-items: baseline; gap: .4rem; min-height: 68px; padding: 1rem .2rem .6rem; }
.result-line b { font-size: 29px; }
.result-line span { color: var(--muted); font-size: 14px; }
.result-line button { margin-left: auto; min-height: 38px; }
.trial-list { display: grid; gap: 12px; }
.trial-card { background: var(--white); border: 1px solid var(--line); }
.trial-card summary { display: grid; grid-template-columns: minmax(260px, 1.2fr) .85fr .8fr auto; gap: 1.2rem; align-items: center; min-height: 112px; padding: 1.1rem 1.25rem; cursor: pointer; list-style: none; }
.trial-card summary::-webkit-details-marker { display: none; }
.trial-card summary::after { content: "+"; display: grid; place-items: center; width: 34px; height: 34px; color: var(--cyan-deep); border: 1px solid var(--line); font-size: 22px; }
.trial-card[open] summary::after { content: "−"; }
.trial-card[open] summary { border-bottom: 1px solid var(--line); }
.trial-title { min-width: 0; }
.trial-title b { display: block; font-size: 20px; line-height: 1.45; }
.trial-title span, .trial-meta span { display: block; color: var(--muted); font-size: 13.5px; line-height: 1.55; }
.trial-meta strong { display: block; font-size: 15px; }
.pills { display: flex; flex-wrap: wrap; gap: .35rem; margin-top: .45rem; }
.pill { display: inline-flex; align-items: center; min-height: 26px; padding: .14rem .42rem; color: #314958; background: #edf0ec; font-size: 11.5px; font-weight: 800; letter-spacing: .035em; }
.pill.good { color: #075f57; background: #dff3ee; }
.pill.bad { color: #943d37; background: #f7e4e1; }
.pill.mixed { color: #875d12; background: #f3ead5; }
.pill.immature { color: #526879; background: #e5ebef; }
.trial-body { padding: 1.3rem 1.5rem 1.5rem; }
.data-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 1px; background: var(--line); border: 1px solid var(--line); }
.data-grid article { min-height: 150px; padding: 1rem; background: #fbf8f2; }
.data-grid h4 { margin: 0 0 .45rem; color: var(--cyan-deep); font-size: 13px; letter-spacing: .08em; }
.data-grid p { margin: 0; color: #304657; font-size: 14.5px; line-height: 1.7; }
.critique { margin: 1rem 0; padding: 1rem 1.15rem; background: #eef4f2; border-left: 5px solid var(--cyan-deep); }
.critique b { display: block; margin-bottom: .25rem; }
.critique p { margin: 0; color: #294351; font-size: 15px; }
.source-row { display: flex; flex-wrap: wrap; gap: .55rem; align-items: center; color: var(--muted); font-size: 13px; }
.source-row a { display: inline-flex; padding: .35rem .55rem; background: var(--navy); color: white; text-decoration: none; }
.database-note { margin: 1.4rem 0 0; color: var(--muted); font-size: 14px; }
.empty { padding: 3rem; text-align: center; color: var(--muted); background: var(--white); border: 1px solid var(--line); }

.lessons { padding: 105px 0; color: white; background: var(--navy); }
.lesson-list { counter-reset: lessons; list-style: none; margin: 0; padding: 0; display: grid; grid-template-columns: 1fr 1fr; gap: 1px; background: rgba(255,255,255,.13); }
.lesson-list li { min-height: 180px; position: relative; padding: 1.5rem 1.5rem 1.5rem 5.3rem; background: #0c2535; }
.lesson-list li::before { counter-increment: lessons; content: "0" counter(lessons); position: absolute; left: 1.4rem; top: 1.25rem; color: var(--cyan); font: 700 26px/1 Georgia, serif; }
.lesson-list b, .lesson-list span { display: block; }
.lesson-list b { margin-bottom: .55rem; font-size: 20px; }
.lesson-list span { color: #b9cbd4; font-size: 15px; line-height: 1.7; }

.geneseeq { padding: 110px 0; }
.value-stack { display: grid; grid-template-columns: repeat(3, 1fr); gap: 18px; }
.value-stack article { min-height: 350px; padding: 1.65rem; background: var(--white); border: 1px solid var(--line); }
.value-stack article:nth-child(2) { transform: translateY(-12px); color: white; background: var(--navy); border-color: var(--navy); box-shadow: var(--shadow); }
.value-stack span { color: var(--cyan-deep); font-size: 13px; font-weight: 800; letter-spacing: .1em; }
.value-stack article:nth-child(2) span { color: var(--cyan); }
.value-stack h3 { margin: 1.25rem 0 .8rem; font-size: 28px; line-height: 1.3; }
.value-stack p { color: var(--muted); font-size: 16px; }
.value-stack article:nth-child(2) p { color: #bdced7; }
.value-stack b { display: block; margin-top: 1.2rem; color: var(--cyan-deep); font-size: 14px; }
.value-stack article:nth-child(2) b { color: var(--cyan); }
.indications { margin-top: 80px; padding: clamp(1.7rem, 4vw, 3.5rem); background: #e7e1d6; border: 1px solid #d2cabd; }
.indication-title { display: grid; grid-template-columns: .8fr 1.2fr; gap: 3rem; align-items: end; margin-bottom: 2rem; }
.indication-title h3 { margin: 0; font-size: 35px; }
.indication-title p { margin: 0; color: var(--muted); }
.indication-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 12px; }
.indication-grid article { min-height: 330px; padding: 1.5rem; background: var(--white); border-top: 5px solid #8e9aa2; }
.indication-grid article.rank-one { border-top-color: var(--cyan-deep); }
.indication-grid span { color: var(--cyan-deep); font-size: 12px; font-weight: 800; letter-spacing: .1em; }
.indication-grid h4 { margin: .65rem 0 .8rem; font-size: 27px; }
.indication-grid p { color: var(--muted); font-size: 15px; }
.indication-grid b { display: block; margin-top: 1rem; color: var(--cyan-deep); font-size: 14px; }

.design { padding: 105px 0; color: white; background: #102d3e; }
.trial-blueprint { display: grid; gap: 1px; background: rgba(255,255,255,.13); }
.trial-blueprint article { display: grid; grid-template-columns: 76px 1fr; gap: 1.2rem; align-items: start; padding: 1.5rem; background: #0d2636; }
.trial-blueprint article > span { color: var(--cyan); font: 700 48px/1 Georgia, serif; }
.trial-blueprint h3 { margin: .1rem 0 .45rem; font-size: 23px; }
.trial-blueprint p { margin: 0; color: #b8cad3; font-size: 15.5px; }
.design-rule { margin-top: 1rem; padding: 1.2rem 1.4rem; color: var(--navy); background: var(--cyan); }

.report { display: grid; grid-template-columns: 250px minmax(0, 940px); gap: 5rem; justify-content: center; align-items: start; padding-top: 110px; padding-bottom: 110px; }
.report > aside { position: sticky; top: 35px; max-height: calc(100vh - 70px); overflow: auto; }
.report > aside > p { margin-top: 0; color: var(--cyan-deep); font-size: 13px; font-weight: 800; letter-spacing: .13em; }
#toc { display: grid; border-left: 1px solid var(--line); }
#toc a { margin-left: -2px; padding: .35rem 0 .35rem .8rem; color: #677785; border-left: 3px solid transparent; font-size: 13.5px; line-height: 1.45; text-decoration: none; }
#toc a:hover, #toc a.active { color: var(--navy); border-left-color: var(--cyan-deep); }
.report-content { min-width: 0; padding: clamp(1.7rem, 4vw, 4rem); background: var(--white); border: 1px solid var(--line); box-shadow: var(--shadow); }
.report-content h2 { margin: 4.5rem 0 1.25rem; padding-top: .8rem; border-top: 1px solid var(--line); font-size: 34px; line-height: 1.3; }
.report-content h2:first-of-type { margin-top: .5rem; border-top: 0; }
.report-content h3 { margin: 2.6rem 0 .9rem; font-size: 24px; line-height: 1.4; }
.report-content p, .report-content li { color: #294150; }
.report-content blockquote { margin: 1.5rem 0; padding: 1rem 1.2rem; background: #e9f3f1; border-left: 5px solid var(--cyan-deep); }
.report-content blockquote p { margin: 0; font-size: 18px; }
.report-content table { display: block; width: 100%; overflow-x: auto; border-collapse: collapse; margin: 1.5rem 0 2.2rem; font-size: 14.5px; line-height: 1.6; }
.report-content th, .report-content td { min-width: 120px; padding: .75rem; text-align: left; vertical-align: top; border: 1px solid var(--line); }
.report-content th { color: white; background: var(--navy); }
.report-content tr:nth-child(even) td { background: #f7f3eb; }

.downloads { margin-bottom: 90px; padding: clamp(2rem, 5vw, 4.5rem); display: grid; grid-template-columns: .8fr 1.2fr; gap: 4rem; color: white; background: var(--navy); }
.downloads > div:first-child p:last-child { color: #b8c9d2; }
.download-grid { display: grid; grid-template-columns: 1fr 1fr; gap: .75rem; }
.download-grid a { min-height: 112px; display: flex; flex-direction: column; justify-content: center; padding: 1rem; color: white; border: 1px solid rgba(255,255,255,.2); text-decoration: none; }
.download-grid a:hover { border-color: var(--cyan); background: rgba(67,214,199,.07); }
.download-grid span { color: #9eb2bd; font-size: 13.5px; }
footer { padding: 2.3rem 0; display: flex; justify-content: space-between; gap: 2rem; color: var(--muted); border-top: 1px solid var(--line); font-size: 14px; }

@media (max-width: 1120px) {
  .hero-grid { grid-template-columns: 1fr; gap: 3rem; }
  .hero-board { max-width: 760px; }
  .verdict-grid, .value-stack, .indication-grid { grid-template-columns: 1fr 1fr; }
  .verdict-card:last-child, .indication-grid article:last-child { grid-column: 1 / -1; }
  .filters { grid-template-columns: 1fr 1fr 1fr; }
  .filters button { align-self: stretch; }
  .trial-card summary { grid-template-columns: 1.3fr .9fr auto; }
  .trial-card summary .trial-meta:nth-of-type(2) { display: none; }
  .report { grid-template-columns: 1fr; gap: 2rem; }
  .report > aside { position: static; max-height: none; }
  #toc { grid-template-columns: 1fr 1fr; border-left: 0; }
  .negative-board { grid-template-columns: 1fr; }
  .negative-board ul { grid-template-columns: 1fr 1fr; }
}

@media (max-width: 760px) {
  body { font-size: 16.5px; line-height: 1.72; }
  .wrap { width: min(100% - 32px, 1440px); }
  .nav { min-height: 72px; }
  .brand b { display: none; }
  .nav-links { gap: .75rem; }
  .nav-links a { font-size: 13.5px; }
  .nav-links a:nth-child(3) { display: none; }
  .hero-grid { min-height: auto; padding: 48px 0 70px; }
  .hero h1 { font-size: clamp(40px, 12vw, 58px); }
  .mini-grid article { min-height: 100px; }
  .verdict { padding: 75px 0 60px; }
  .verdict-grid, .value-stack, .indication-grid, .method-grid, .method-items, .lesson-list, .downloads { grid-template-columns: 1fr; }
  .value-stack article:nth-child(2) { transform: none; }
  .signal-strip { grid-template-columns: 1fr; }
  .signal-strip i { transform: rotate(90deg); justify-self: center; }
  .negative-board ul { grid-template-columns: 1fr; }
  .method-grid { gap: 2rem; }
  .evidence { padding: 75px 0; }
  .evidence-head { display: block; }
  .filters { grid-template-columns: 1fr; }
  .trial-card summary { grid-template-columns: 1fr auto; gap: .6rem; }
  .trial-card summary .trial-meta { display: none; }
  .data-grid { grid-template-columns: 1fr; }
  .lesson-list li { min-height: auto; }
  .geneseeq { padding: 75px 0; }
  .indication-title { grid-template-columns: 1fr; gap: 1rem; }
  .trial-blueprint article { grid-template-columns: 52px 1fr; }
  .trial-blueprint article > span { font-size: 39px; }
  .report { width: 100%; padding-top: 70px; padding-bottom: 70px; }
  .report > aside { width: calc(100% - 32px); margin-inline: auto; }
  #toc { grid-template-columns: 1fr; }
  .report-content { border-inline: 0; padding: 1.2rem 1rem; box-shadow: none; }
  .report-content h2 { font-size: 28px; }
  .downloads { gap: 2rem; padding: 1.5rem; }
  .download-grid { grid-template-columns: 1fr; }
  footer { display: block; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { transition: none !important; animation: none !important; }
}